<html>
<head>
<meta http-equiv="content-type" content="text/html; charset=UTF-8">
</head>
<body>
<span style="left: 238.027px; top: 123.867px; font-size: 20px;
font-family: sans-serif; transform: scaleX(0.845638);"
role="presentation" dir="ltr"></span><br>
<span style="left: 238.027px; top: 123.867px; font-size: 20px;
font-family: sans-serif; transform: scaleX(0.845638);"
role="presentation" dir="ltr"></span><br>
<span style="left: 238.027px; top: 123.867px; font-size: 20px;
font-family: sans-serif; transform: scaleX(0.845638);"
role="presentation" dir="ltr"></span><span style="left: 238.027px;
top: 123.867px; font-size: 20px; font-family: sans-serif;
transform: scaleX(0.845638);" role="presentation" dir="ltr">Call
for a postdoctoral position at </span><span style="left:
519.843px; top: 123.867px; font-size: 20px; font-family:
sans-serif; transform: scaleX(0.857023);" role="presentation"
dir="ltr">the Analytical Genomics Lab</span><span style="left:
754.14px; top: 123.867px; font-size: 20px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<div class="moz-forward-container"> <span style="left: 174.736px;
top: 148.267px; font-size: 20px; font-family: sans-serif;
transform: scaleX(0.865609);" role="presentation" dir="ltr">Department
of Computational and Quantitative Biology, Sorbonne Univers</span><span
style="left: 795.517px; top: 148.267px; font-size: 20px;
font-family: sans-serif;" role="presentation" dir="ltr">i</span><span
style="left: 800.429px; top: 148.267px; font-size: 20px;
font-family: sans-serif; transform: scaleX(0.9117);"
role="presentation" dir="ltr">té</span><span style="left:
817.431px; top: 148.267px; font-size: 20px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 283.894px; top: 172.293px; font-size: 18.4px;
font-family: sans-serif; transform: scaleX(0.829251);"
role="presentation" dir="ltr">A.Carbone </span><span
style="left: 366.277px; top: 172.293px; font-size: 18.4px;
font-family: sans-serif;" role="presentation" dir="ltr">–</span><span
style="left: 375.408px; top: 172.293px; font-size: 18.4px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 379.553px; top: 172.293px; font-size: 18.4px;
font-family: sans-serif; transform: scaleX(0.852184);"
role="presentation" dir="ltr">alessandra.carbone@sorbonne</span><span
style="left: 612.139px; top: 172.293px; font-size: 18.4px;
font-family: sans-serif;" role="presentation" dir="ltr">-</span><span
style="left: 617.752px; top: 172.293px; font-size: 18.4px;
font-family: sans-serif; transform: scaleX(0.842648);"
role="presentation" dir="ltr">universite.fr</span><span
style="left: 708.273px; top: 172.293px; font-size: 18.4px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 193.947px; font-size: 15.2px;
font-family: monospace;" role="presentation" dir="ltr"> </span><span
style="left: 120px; top: 212.347px; font-size: 15.2px;
font-family: monospace;" role="presentation" dir="ltr"></span><br
role="presentation">
<span style="left: 120px; top: 230.72px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">W</span><span
style="left: 134.681px; top: 230.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.804787);"
role="presentation" dir="ltr">e o</span><span style="left:
154.801px; top: 230.72px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.853568);" role="presentation"
dir="ltr">ffer</span><span style="left: 178.743px; top:
230.72px; font-size: 16.8px; font-family: sans-serif;"
role="presentation" dir="ltr"> </span><span style="left:
181.936px; top: 230.72px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.808915);" role="presentation"
dir="ltr">a postdoctoral position in the Analytical Genomics
lab, at the LCQB in Sorbonne Université</span><span style="left:
777.432px; top: 230.72px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 780.625px; top: 230.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.888443);"
role="presentation" dir="ltr">(SU)</span><span style="left:
808.726px; top: 230.72px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.736883);" role="presentation"
dir="ltr">. </span><span style="left: 815.996px; top: 230.72px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.788314);" role="presentation" dir="ltr">The goal </span><br
role="presentation">
<span style="left: 120px; top: 251.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.834696);"
role="presentation" dir="ltr">of th</span><span style="left:
152.154px; top: 251.12px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.815096);" role="presentation"
dir="ltr">e </span><span style="left: 164.736px; top: 251.12px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.825586);" role="presentation" dir="ltr">project is to
provide a proof of concept that for a given gene, using combined
results of known synthetic </span><br role="presentation">
<span style="left: 120px; top: 271.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.820543);"
role="presentation" dir="ltr">biology, DNA</span><span
style="left: 208.097px; top: 271.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">-</span><span
style="left: 213.199px; top: 271.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.845237);"
role="presentation" dir="ltr">bar coding, NGS and com</span><span
style="left: 388.144px; top: 271.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.821686);"
role="presentation" dir="ltr">putational biology, </span><span
style="left: 520.082px; top: 271.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.827451);"
role="presentation" dir="ltr">one </span><span style="left:
550.985px; top: 271.52px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.844805);" role="presentation"
dir="ltr">can determine the pathogenicity of all variants </span><br
role="presentation">
<span style="left: 120px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.814045);"
role="presentation" dir="ltr">generated by single nucleotide
mutations.</span><span style="left: 399.884px; top: 291.92px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr"> </span><span style="left: 403.186px; top: 291.92px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.82065);" role="presentation" dir="ltr">The</span><span
style="left: 428.137px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 431.44px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.817887);"
role="presentation" dir="ltr">consortium involv</span><span
style="left: 550.432px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">e</span><span
style="left: 558.668px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.733553);"
role="presentation" dir="ltr">s </span><span style="left:
568.415px; top: 291.92px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.87804);" role="presentation"
dir="ltr">SU</span><span style="left: 586.555px; top: 291.92px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.774134);" role="presentation" dir="ltr">, CIRI </span><span
style="left: 623.164px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">-</span><span
style="left: 628.267px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 631.569px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.833986);"
role="presentation" dir="ltr">ENS Lyon, IRMB </span><span
style="left: 739.498px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">–</span><span
style="left: 747.799px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 751.101px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">U</span><span
style="left: 761.697px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">.</span><span
style="left: 765.774px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 769.076px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.843042);"
role="presentation" dir="ltr">de Montpellier</span><span
style="left: 868.09px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">.</span><span
style="left: 872.167px; top: 291.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 312.32px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 332.71px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.828097);"
role="presentation" dir="ltr">Description. </span><span
style="left: 206.774px; top: 332.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.87042);"
role="presentation" dir="ltr">Monogenic diseases are due to
mutations that can affect up t</span><span style="left:
641.617px; top: 332.72px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.860647);" role="presentation"
dir="ltr">o 4,000 different genes. Due to a </span><br
role="presentation">
<span style="left: 120px; top: 353.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.81227);"
role="presentation" dir="ltr">substantial number of genes for
which mutations trigger different diseases, more than 6,000
monogenic diseases </span><br role="presentation">
<span style="left: 120px; top: 373.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.826739);"
role="presentation" dir="ltr">have been characterized (<a
class="moz-txt-link-freetext"
href="https://www.omim.org/statistics/geneMap">https://www.omim.org/statistics/geneMap</a>).
</span><span style="left: 598.292px; top: 373.11px; font-size:
16.4706px; font-family: sans-serif; transform:
scaleX(0.836116);" role="presentation" dir="ltr">The major
roadblock in genetic diagnosis </span><br role="presentation">
<span style="left: 120px; top: 393.51px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.756868);"
role="presentation" dir="ltr">is </span><span style="left:
133.422px; top: 393.51px; font-size: 16.4706px; font-family:
sans-serif; transform: scaleX(0.832282);" role="presentation"
dir="ltr">the number of variants of uncertain significance (VUS)</span><span
style="left: 491.897px; top: 393.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.809818);"
role="presentation" dir="ltr">. Identifying a VUS in a patient
leaves the practitioner with </span><br role="presentation">
<span style="left: 120px; top: 413.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.820284);"
role="presentation" dir="ltr">no actionable diagnosis (decision
to treat or search for an alternative diagnosis), leading to a
stressful and costly </span><br role="presentation">
<span style="left: 120px; top: 434.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.822758);"
role="presentation" dir="ltr">diagnostic wandering a</span><span
style="left: 275.76px; top: 434.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.831678);"
role="presentation" dir="ltr">nd a loss of chance for the
patient.</span><span style="left: 512.624px; top: 434.32px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr"> </span><span style="left: 517.095px; top: 434.32px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.818412);" role="presentation" dir="ltr">By providing </span><span
style="left: 605.22px; top: 434.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.816722);"
role="presentation" dir="ltr">in vitro</span><span style="left:
652.245px; top: 434.32px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 656.716px; top: 434.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.827654);"
role="presentation" dir="ltr">pathogenicity score and novel </span><span
style="left: 863.874px; top: 434.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.771495);"
role="presentation" dir="ltr">in </span><br role="presentation">
<span style="left: 120px; top: 454.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.782419);"
role="presentation" dir="ltr">silico</span><span style="left:
152.886px; top: 454.72px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 158.006px; top: 454.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.836275);"
role="presentation" dir="ltr">predictions for each coding
sequence variant described in </span><span style="left:
558.362px; top: 454.72px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.834097);" role="presentation"
dir="ltr">a specific gene</span><span style="left: 659.245px;
top: 454.72px; font-size: 16.8px; font-family: sans-serif;
transform: scaleX(0.830049);" role="presentation" dir="ltr">,
this project should, ultimately, </span><br role="presentation">
<span style="left: 120px; top: 475.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.824429);"
role="presentation" dir="ltr">provide a way to </span><span
style="left: 234.925px; top: 475.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.82368);"
role="presentation" dir="ltr">greatly reduce the number of </span><span
style="left: 435.714px; top: 475.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.849555);"
role="presentation" dir="ltr">VUS.</span><span style="left:
467.168px; top: 475.12px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 470.936px; top: 475.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 495.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 515.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.847999);"
role="presentation" dir="ltr">We shall focus on a specific gene,
MEFV</span><span style="left: 393.903px; top: 515.92px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.765006);" role="presentation" dir="ltr">: </span><span
style="left: 403.084px; top: 515.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.836606);"
role="presentation" dir="ltr">i) this gene carries a large
proportion of VUS (≈50%) (despite intense </span><br
role="presentation">
<span style="left: 120px; top: 535.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.813744);"
role="presentation" dir="ltr">studies on this gene and its
variants since its discovery 25 years ago), ii) </span><span
style="left: 605.684px; top: 535.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 609.866px; top: 535.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">m</span><span
style="left: 623.05px; top: 535.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.82437);"
role="presentation" dir="ltr">utations of this gene can cause
three </span><br role="presentation">
<span style="left: 120px; top: 556.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.820066);"
role="presentation" dir="ltr">different diseases: </span><span
style="left: 247.141px; top: 556.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.85351);"
role="presentation" dir="ltr">familial Mediterranean fever
(FMF), FMF</span><span style="left: 520.441px; top: 556.32px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr">-</span><span style="left: 525.543px; top: 556.32px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.817269);" role="presentation" dir="ltr">like disease
and Pyrin</span><span style="left: 669.269px; top: 556.32px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr">-</span><span style="left: 674.372px; top: 556.32px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.821788);" role="presentation" dir="ltr">Associated
Autoinflammation </span><br role="presentation">
<span style="left: 120px; top: 576.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.816859);"
role="presentation" dir="ltr">with neutrophilic dermatosis
(PAAND) with different inheritance patterns, iii) FMF is the
most common hereditary </span><br role="presentation">
<span style="left: 120px; top: 597.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.830441);"
role="presentation" dir="ltr">autoinflammatory disease (AID) and
</span><span style="left: 367.178px; top: 597.12px; font-size:
16.8px; font-family: sans-serif; transform: scaleX(0.897286);"
role="presentation" dir="ltr">MEFV</span><span style="left:
406.305px; top: 597.12px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 410.792px; top: 597.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.817215);"
role="presentation" dir="ltr">gene is thus</span><span
style="left: 492.071px; top: 597.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 496.558px; top: 597.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.831295);"
role="presentation" dir="ltr">very frequently sequenced in AID
patients. </span><span style="left: 789.159px; top: 597.11px;
font-size: 16.4706px; font-family: sans-serif; transform:
scaleX(0.844239);" role="presentation" dir="ltr">Importantly, </span><br
role="presentation">
<span style="left: 120px; top: 617.51px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.839369);"
role="presentation" dir="ltr">the technological and
computational approaches developed in this "proof of concept"
project should be </span><br role="presentation">
<span style="left: 120px; top: 637.91px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.828257);"
role="presentation" dir="ltr">transferable to all the genes
involved in genetic diseases for which functional assays exist
or c</span><span style="left: 745.041px; top: 637.91px;
font-size: 16.4706px; font-family: sans-serif; transform:
scaleX(0.828863);" role="presentation" dir="ltr">an be designed.</span><span
style="left: 850.558px; top: 637.91px; font-size: 16.4706px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 658.32px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 678.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.810219);"
role="presentation" dir="ltr">The postdoc will be involved in
the </span><span style="left: 354.283px; top: 678.32px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.776519);" role="presentation" dir="ltr">in silico</span><span
style="left: 402.877px; top: 678.32px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 406.458px; top: 678.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.817864);"
role="presentation" dir="ltr">part of the project and will work
in collaboration with the</span><span style="left: 787.644px;
top: 678.32px; font-size: 16.8px; font-family: sans-serif;"
role="presentation" dir="ltr"> </span><span style="left:
791.225px; top: 678.32px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.819989);" role="presentation"
dir="ltr">members of </span><br role="presentation">
<span style="left: 120px; top: 698.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.841426);"
role="presentation" dir="ltr">the consortium</span><span
style="left: 224.106px; top: 698.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.736883);"
role="presentation" dir="ltr">. </span><span style="left:
233.599px; top: 698.71px; font-size: 16.4706px; font-family:
sans-serif; transform: scaleX(0.896124);" role="presentation"
dir="ltr">(S)</span><span style="left: 251.129px; top: 698.71px;
font-size: 16.4706px; font-family: sans-serif; transform:
scaleX(0.86835);" role="presentation" dir="ltr">he will develop
novel computational methods leading to the</span><span
style="left: 666.714px; top: 698.71px; font-size: 16.4706px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 672.142px; top: 698.71px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.863278);"
role="presentation" dir="ltr">reconstruction of the protein </span><br
role="presentation">
<span style="left: 120px; top: 719.11px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.837407);"
role="presentation" dir="ltr">mutational landscapes and the
evaluation of protein mutations in multimeric proteins. </span><span
style="left: 702.08px; top: 719.11px; font-size: 16.4706px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 739.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 759.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.849042);"
role="presentation" dir="ltr">(S)he will apply the new tools to
the </span><span style="left: 372.123px; top: 759.92px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.8198);" role="presentation" dir="ltr">study</span><span
style="left: 408.712px; top: 759.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 413.514px; top: 759.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.797698);"
role="presentation" dir="ltr">of </span><span style="left:
431.988px; top: 759.92px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.841113);" role="presentation"
dir="ltr">the behavior of the multimeric protein </span><span
style="left: 699.816px; top: 759.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.842994);"
role="presentation" dir="ltr">Pyrin</span><span style="left:
733.711px; top: 759.92px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.860512);" role="presentation"
dir="ltr">, coded in the MEFV</span><span style="left:
872.167px; top: 759.92px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 780.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.810209);"
role="presentation" dir="ltr">gene. </span><span style="left:
161.29px; top: 780.32px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.842574);" role="presentation"
dir="ltr">For Pyrin, w</span><span style="left: 241.552px; top:
780.32px; font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.834294);" role="presentation" dir="ltr">e wish to
decrypt the </span><span style="left: 389.32px; top: 780.32px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.8294);" role="presentation" dir="ltr">surfaces at the
amino</span><span style="left: 535.326px; top: 780.32px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr">-</span><span style="left: 540.428px; top: 780.32px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.818529);" role="presentation" dir="ltr">acid residue
level and gain novel insights into the </span><br
role="presentation">
<span style="left: 120px; top: 800.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.821368);"
role="presentation" dir="ltr">mechanisms underlying the
pathogenicity of the different variants. In addition to
providing novel hypotheses on </span><br role="presentation">
<span style="left: 120px; top: 820.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.827891);"
role="presentation" dir="ltr">Pyrin functions and dysfunctions,
</span><span style="left: 350.822px; top: 820.72px; font-size:
16.8px; font-family: sans-serif;" role="presentation" dir="ltr">a</span><span
style="left: 358.667px; top: 820.72px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 363.806px; top: 820.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.808068);"
role="presentation" dir="ltr">back</span><span style="left:
394.747px; top: 820.72px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr">-</span><span
style="left: 399.849px; top: 820.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.831031);"
role="presentation" dir="ltr">and</span><span style="left:
425.012px; top: 820.72px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr">-</span><span
style="left: 430.115px; top: 820.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.831492);"
role="presentation" dir="ltr">for</span><span style="left:
449.532px; top: 820.72px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.842356);" role="presentation"
dir="ltr">th approach between biological data and </span><span
style="left: 735.336px; top: 820.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.801465);"
role="presentation" dir="ltr">in silico</span><span style="left:
785.487px; top: 820.72px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 790.627px; top: 820.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.806904);"
role="presentation" dir="ltr">modelling </span><span
style="left: 862.043px; top: 820.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.741651);"
role="presentation" dir="ltr">is </span><br role="presentation">
<span style="left: 120px; top: 841.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.819952);"
role="presentation" dir="ltr">expected to</span><span
style="left: 203.348px; top: 841.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 207.144px; top: 841.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 210.963px; top: 841.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.821687);"
role="presentation" dir="ltr">improve the performance of </span><span
style="left: 416.125px; top: 841.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 420.063px; top: 841.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.840894);"
role="presentation" dir="ltr">in silico</span><span style="left:
472.69px; top: 841.12px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 476.486px; top: 841.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 480.305px; top: 841.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.813402);"
role="presentation" dir="ltr">prediction of pathogenic
mutations. Five </span><span style="left: 770.717px; top:
841.12px; font-size: 16.8px; font-family: sans-serif;"
role="presentation" dir="ltr"> </span><span style="left:
774.535px; top: 841.12px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.827602);" role="presentation"
dir="ltr">computational </span><br role="presentation">
<span style="left: 120px; top: 861.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.816859);"
role="presentation" dir="ltr">approaches will be performed.
Their aim is threefold and concern: 1. the protein structur</span><span
style="left: 713.403px; top: 861.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.822919);"
role="presentation" dir="ltr">e: the interaction of the </span><br
role="presentation">
<span style="left: 120px; top: 881.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.84545);"
role="presentation" dir="ltr">different domains, the potential
conformational changes of the protein and the identification of
unstructured </span><br role="presentation">
<span style="left: 120px; top: 902.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.826446);"
role="presentation" dir="ltr">regions; 2. the interaction of the
protein with other partners: the binding sites of the protein
and the modelling </span><br role="presentation">
<span style="left: 120px; top: 922.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.812024);"
role="presentation" dir="ltr">of th</span><span style="left:
151.276px; top: 922.72px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.814804);" role="presentation"
dir="ltr">e physical interaction of the pyrin domains with known
protein partners; 3. the reconstruction of the protein </span><br
role="presentation">
<span style="left: 120px; top: 943.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.814796);"
role="presentation" dir="ltr">mutational landscape. </span><span
style="left: 275.205px; top: 943.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 278.64px; top: 943.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">M</span><span
style="left: 292.719px; top: 943.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.821888);"
role="presentation" dir="ltr">ultiple</span><span style="left:
334.784px; top: 943.12px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 338.581px; top: 943.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 341.912px; top: 943.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.805804);"
role="presentation" dir="ltr">potential novel insights generated
by the</span><span style="left: 632.686px; top: 943.12px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr"> </span><span style="left: 636.482px; top: 943.12px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr"> </span><span style="left: 639.813px; top: 943.12px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.839419);" role="presentation" dir="ltr">five</span><span
style="left: 664.04px; top: 943.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 667.837px; top: 943.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 671.168px; top: 943.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.822664);"
role="presentation" dir="ltr">approaches </span><span
style="left: 752.748px; top: 943.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 756.168px; top: 943.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.811388);"
role="presentation" dir="ltr">were highlighted </span><br
role="presentation">
<span style="left: 120px; top: 963.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.814098);"
role="presentation" dir="ltr">although fully unexpected
hypotheses mig</span><span style="left: 403.309px; top:
963.12px; font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.823417);" role="presentation" dir="ltr">ht emerge from
the analyses</span><span style="left: 595.44px; top: 963.12px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr">:</span><span style="left: 599.818px; top: 963.12px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr"> </span><br role="presentation">
<span style="left: 120px; top: 983.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.784047);"
role="presentation" dir="ltr">1.</span><span style="left:
132.524px; top: 983.52px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 136.292px; top: 983.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.819603);"
role="presentation" dir="ltr">Reconstruction of the landscape of
phenotypic effects from evolutionary conservation and epistatic
signals.</span><span style="left: 853.976px; top: 983.52px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr"> </span><br role="presentation">
<span style="left: 120px; top: 1007.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.764815);"
role="presentation" dir="ltr">2. </span><span style="left:
136.292px; top: 1007.12px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.825096);" role="presentation"
dir="ltr">Prediction of </span><span style="left: 225.876px;
top: 1007.12px; font-size: 16.8px; font-family: sans-serif;
transform: scaleX(0.826403);" role="presentation" dir="ltr">protein
</span><span style="left: 278.789px; top: 1007.12px; font-size:
16.8px; font-family: sans-serif; transform: scaleX(0.822001);"
role="presentation" dir="ltr">interaction sites</span><span
style="left: 386.073px; top: 1007.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 389.841px; top: 1007.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.829643);"
role="presentation" dir="ltr">without knowledge of the partner</span><span
style="left: 616.574px; top: 1007.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.736883);"
role="presentation" dir="ltr">. </span><span style="left:
624.419px; top: 1007.12px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 1027.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">3</span><span
style="left: 128.447px; top: 1027.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">.</span><span
style="left: 132.524px; top: 1027.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 136.292px; top: 1027.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.813311);"
role="presentation" dir="ltr">3D modelling and molecular dynamic
simulations</span><span style="left: 464.84px; top: 1027.52px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr"> </span><span style="left: 468.608px; top: 1027.52px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.823106);" role="presentation" dir="ltr">of the known
pyrin protein partners</span><span style="left: 708.542px; top:
1027.52px; font-size: 16.8px; font-family: sans-serif;"
role="presentation" dir="ltr">.</span><span style="left:
712.619px; top: 1027.52px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 716.387px; top: 1027.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 1047.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.764815);"
role="presentation" dir="ltr">4. </span><span style="left:
136.292px; top: 1047.92px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.827325);" role="presentation"
dir="ltr">Intra and inter</span><span style="left: 232.581px;
top: 1047.92px; font-size: 16.8px; font-family: sans-serif;"
role="presentation" dir="ltr">-</span><span style="left:
237.684px; top: 1047.92px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.81931);" role="presentation"
dir="ltr">molecular analyses of the co</span><span style="left:
427.886px; top: 1047.92px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr">-</span><span
style="left: 432.988px; top: 1047.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.824444);"
role="presentation" dir="ltr">evolution of amino</span><span
style="left: 559.356px; top: 1047.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">-</span><span
style="left: 564.458px; top: 1047.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.810312);"
role="presentation" dir="ltr">acid residues.</span><span
style="left: 655.677px; top: 1047.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 659.445px; top: 1047.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 1067.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.784047);"
role="presentation" dir="ltr">5.</span><span style="left:
132.524px; top: 1067.92px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 136.292px; top: 1067.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">D</span><span
style="left: 146.408px; top: 1067.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.808793);"
role="presentation" dir="ltr">ocking experiments</span><span
style="left: 276.982px; top: 1067.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">.</span><span
style="left: 281.06px; top: 1067.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 1088.32px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 120px; top: 1109.09px; font-size: 18.4px;
font-family: monospace;" role="presentation" dir="ltr"></span><br
role="presentation">
<span style="left: 120px; top: 1131.11px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.885972);"
role="presentation" dir="ltr">Profile of the </span><span
style="left: 217.923px; top: 1131.11px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.838949);"
role="presentation" dir="ltr">postdoctoral </span><span
style="left: 309.271px; top: 1131.11px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.852853);"
role="presentation" dir="ltr">candidate</span><span style="left:
375.49px; top: 1131.12px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.940183);" role="presentation"
dir="ltr">: w</span><span style="left: 397.605px; top:
1131.12px; font-size: 16.8px; font-family: sans-serif;
transform: scaleX(0.87126);" role="presentation" dir="ltr">e
look for a </span><span style="left: 485.875px; top: 1131.12px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.851697);" role="presentation" dir="ltr">postdoctoral
candidate from the field of bioinformatics</span><span
style="left: 868.09px; top: 1131.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.736883);"
role="presentation" dir="ltr">, </span><br role="presentation">
<span style="left: 120px; top: 1151.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.830565);"
role="presentation" dir="ltr">computer science</span><span
style="left: 238.937px; top: 1151.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 242.705px; top: 1151.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.802832);"
role="presentation" dir="ltr">or physics</span><span
style="left: 309.233px; top: 1151.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 313.001px; top: 1151.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.81759);"
role="presentation" dir="ltr">with an experience in </span><span
style="left: 460.12px; top: 1151.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.816534);"
role="presentation" dir="ltr">protein structures and/or </span><span
style="left: 634.184px; top: 1151.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.811302);"
role="presentation" dir="ltr">genomics.</span><span style="left:
702.056px; top: 1151.52px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 1171.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 1192.31px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.873773);"
role="presentation" dir="ltr">General information on the
scientific environment</span><span style="left: 467.988px; top:
1192.31px; font-size: 16.4706px; font-family: sans-serif;"
role="presentation" dir="ltr">.</span><span style="left:
472.074px; top: 1192.32px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 478.101px; top: 1192.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.803203);"
role="presentation" dir="ltr">The </span><span style="left:
509.08px; top: 1192.31px; font-size: 16.4706px; font-family:
sans-serif; transform: scaleX(0.853385);" role="presentation"
dir="ltr">Analytical Genomics</span><span style="left:
646.394px; top: 1192.32px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 652.421px; top: 1192.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.872654);"
role="presentation" dir="ltr">team at LCQB</span><span
style="left: 748.461px; top: 1192.32px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 754.488px; top: 1192.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.841483);"
role="presentation" dir="ltr">works on various </span><br
role="presentation">
<span style="left: 120px; top: 1212.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.838627);"
role="presentation" dir="ltr">problems connected with the
functioning and evolution of biological systems. We use
mathematical concepts, </span><br role="presentation">
<span style="left: 120px; top: 1232.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.835678);"
role="presentation" dir="ltr">coming from statistics and
combinatorics, algorithm</span><span style="left: 477.598px;
top: 1232.72px; font-size: 16.8px; font-family: sans-serif;"
role="presentation" dir="ltr">s</span><span style="left:
484.043px; top: 1232.72px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 489.821px; top: 1232.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.844551);"
role="presentation" dir="ltr">(deep learning and </span><span
style="left: 625.399px; top: 1232.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.823154);"
role="presentation" dir="ltr">optimisation</span><span
style="left: 709.562px; top: 1232.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.810139);"
role="presentation" dir="ltr">) </span><span style="left:
720.32px; top: 1232.72px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.832492);" role="presentation"
dir="ltr">and molecular physics </span><br role="presentation">
<span style="left: 120px; top: 1253.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.854611);"
role="presentation" dir="ltr">approaches to study basic
principles of cellular functioning starting from genomic data.
Our projects aim at </span><span style="left: 120px; top:
123.12px; font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.843727);" role="presentation" dir="ltr">understanding
the basic principles of evolution and co</span><span
style="left: 494.906px; top: 123.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">-</span><span
style="left: 500.008px; top: 123.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.851532);"
role="presentation" dir="ltr">evolution of molecular structures
in the cell. They are </span><span style="left: 120px; top:
143.52px; font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.820554);" role="presentation" dir="ltr">intimately lin</span><span
style="left: 207.044px; top: 143.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.816774);"
role="presentation" dir="ltr">ked to each other. Applications
are in</span><span style="left: 456.89px; top: 143.52px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr"> </span><span style="left: 460.658px; top: 143.51px;
font-size: 16.4706px; font-family: sans-serif; transform:
scaleX(0.850487);" role="presentation" dir="ltr">medicine</span><span
style="left: 522.14px; top: 143.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 525.908px; top: 143.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.831031);"
role="presentation" dir="ltr">and</span><span style="left:
551.071px; top: 143.52px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 554.839px; top: 143.51px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.860564);"
role="presentation" dir="ltr">environment</span><span
style="left: 641.484px; top: 143.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">.</span><span
style="left: 645.562px; top: 143.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 163.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.83797);"
role="presentation" dir="ltr">See </span><span style="left:
147.783px; top: 163.92px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.825782);" role="presentation"
dir="ltr"><a class="moz-txt-link-abbreviated"
href="http://www.lcqb.upmc.fr/AnalGenom/projects.html">www.lcqb.upmc.fr/AnalGenom/projects.html</a></span><span
style="left: 451.478px; top: 163.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 183.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 204.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.803203);"
role="presentation" dir="ltr">The </span><span style="left:
148.701px; top: 204.32px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 155.73px; top: 204.31px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.86964);"
role="presentation" dir="ltr">Computational and Quantitative
Biology unit</span><span style="left: 482.596px; top: 204.32px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr">,</span><span style="left: 486.673px; top: 204.32px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr"> </span><span style="left: 490.47px; top: 204.32px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr"> </span><span style="left: 497.453px; top: 204.32px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.87804);" role="presentation" dir="ltr">SU</span><span
style="left: 515.592px; top: 204.32px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">-</span><span
style="left: 520.695px; top: 204.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.809725);"
role="presentation" dir="ltr">CNRS </span><span style="left:
560.385px; top: 204.32px; font-size: 16.8px; font-family:
sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 567.444px; top: 204.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.847977);"
role="presentation" dir="ltr">UMR7238, offers a
multidisciplinary work </span><br role="presentation">
<span style="left: 120px; top: 224.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.840355);"
role="presentation" dir="ltr">environment made up of a part of </span><span
style="left: 357.13px; top: 224.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.827878);"
role="presentation" dir="ltr">experiment</span><span
style="left: 434.213px; top: 224.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.801435);"
role="presentation" dir="ltr">alist</span><span style="left:
461.337px; top: 224.72px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.833199);" role="presentation"
dir="ltr">s (genetics and synthetic biology) and a part of theor</span><span
style="left: 821.06px; top: 224.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.832821);"
role="presentation" dir="ltr">etician</span><span style="left:
865.722px; top: 224.72px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.733553);" role="presentation"
dir="ltr">s </span><br role="presentation">
<span style="left: 120px; top: 245.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.821732);"
role="presentation" dir="ltr">(computer science, mathematics,
physics), around several themes: evolution, genome and
population dynamics, </span><br role="presentation">
<span style="left: 120px; top: 265.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.826674);"
role="presentation" dir="ltr">regulatory networks, structural
bioinformatics, environment, modeling </span><span style="left:
601.531px; top: 265.52px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.815532);" role="presentation"
dir="ltr">of complex biological systems, synthetic </span><br
role="presentation">
<span style="left: 120px; top: 285.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.812315);"
role="presentation" dir="ltr">biology and protein engineering. </span><span
style="left: 341.427px; top: 285.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.822874);"
role="presentation" dir="ltr">Further information can be found
at </span><span style="left: 586.968px; top: 285.92px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.836289);" role="presentation" dir="ltr"><a
class="moz-txt-link-abbreviated"
href="http://www.lcqb.upmc.fr">www.lcqb.upmc.fr</a></span><span
style="left: 710.536px; top: 285.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 306.32px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 326.31px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.863978);"
role="presentation" dir="ltr">Sorbonne Université</span><span
style="left: 258.572px; top: 326.32px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 264.019px; top: 326.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.841066);"
role="presentation" dir="ltr">(SU, </span><span style="left:
296.663px; top: 326.32px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.848985);" role="presentation"
dir="ltr"><a class="moz-txt-link-abbreviated"
href="http://www.sorbonne">www.sorbonne</a></span><span
style="left: 399.463px; top: 326.32px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">-</span><span
style="left: 404.565px; top: 326.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.825275);"
role="presentation" dir="ltr">universite.fr</span><span
style="left: 485.514px; top: 326.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.837213);"
role="presentation" dir="ltr">) is a fully multidisciplinary
research</span><span style="left: 731.881px; top: 326.32px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr">-</span><span style="left: 736.983px; top: 326.32px;
font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.827128);" role="presentation" dir="ltr">intensive
university, </span><br role="presentation">
<span style="left: 120px; top: 346.72px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.847386);"
role="presentation" dir="ltr">located in several campuses at the
heart of Paris. Sorbonne Université covers all major
disciplinary fields and </span><br role="presentation">
<span style="left: 120px; top: 367.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.812172);"
role="presentation" dir="ltr">offers transversal academic and
research programs with three faculties: Humanities</span><span
style="left: 673.05px; top: 367.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 676.066px; top: 367.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.814884);"
role="presentation" dir="ltr">and Social Sciences, Medicine </span><br
role="presentation">
<span style="left: 120px; top: 387.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.843349);"
role="presentation" dir="ltr">and Sciences & Engineering,
bringing together the best talents in a wide array of these
disciplines. With more </span><br role="presentation">
<span style="left: 120px; top: 407.92px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.847707);"
role="presentation" dir="ltr">than 55 600 students (among 10 200
international students), 4700 doctoral students and 6400
researchers, </span><br role="presentation">
<span style="left: 120px; top: 428.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.829568);"
role="presentation" dir="ltr">Sorbonne </span><span
style="left: 188.652px; top: 428.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.816475);"
role="presentation" dir="ltr">Université is one of the leading
French universities. </span><span style="left: 533.599px; top:
428.32px; font-size: 16.8px; font-family: sans-serif;"
role="presentation" dir="ltr"> </span><br role="presentation">
<span style="left: 120px; top: 448.72px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 469.11px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.844665);"
role="presentation" dir="ltr">Location</span><span style="left:
177.178px; top: 469.11px; font-size: 16.4706px; font-family:
sans-serif;" role="presentation" dir="ltr">:</span><span
style="left: 181.564px; top: 469.11px; font-size: 16.4706px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 185.34px; top: 469.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.83144);"
role="presentation" dir="ltr">the </span><span style="left:
211.479px; top: 469.12px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.821401);" role="presentation"
dir="ltr">Pierre and Marie Campus is located in the heart of
Paris, the 5</span><span style="left: 626.47px; top: 467.72px;
font-size: 10.8px; font-family: sans-serif; transform:
scaleX(0.855481);" role="presentation" dir="ltr">th</span><span
style="left: 635.658px; top: 469.12px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 639.426px; top: 469.12px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.82262);"
role="presentation" dir="ltr">quarter, in front of the Seine
river.</span><span style="left: 869.577px; top: 469.12px;
font-size: 16.8px; font-family: sans-serif;" role="presentation"
dir="ltr"> </span><br role="presentation">
<span style="left: 120px; top: 489.11px; font-size: 16.4706px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 509.51px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.846308);"
role="presentation" dir="ltr">Position</span><span style="left:
173.849px; top: 509.52px; font-size: 16.8px; font-family:
sans-serif; transform: scaleX(0.81134);" role="presentation"
dir="ltr">: 2 years postdoctoral position </span><span
style="left: 380.262px; top: 509.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.792056);"
role="presentation" dir="ltr">possibly </span><span
style="left: 437.635px; top: 509.52px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.816598);"
role="presentation" dir="ltr">starting from January 202</span><span
style="left: 609.331px; top: 509.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">2</span><span
style="left: 617.778px; top: 509.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">.</span><span
style="left: 621.856px; top: 509.52px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 529.92px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><br
role="presentation">
<span style="left: 120px; top: 550.31px; font-size: 16.4706px;
font-family: sans-serif; transform: scaleX(0.847309);"
role="presentation" dir="ltr">Contact</span><span style="left:
172.214px; top: 550.31px; font-size: 16.4706px; font-family:
sans-serif;" role="presentation" dir="ltr">:</span><span
style="left: 176.6px; top: 550.32px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr"> </span><span
style="left: 180.368px; top: 550.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.828298);"
role="presentation" dir="ltr">Alessandra Carbone,
alessandra.carbone@</span><span style="left: 466.948px; top:
550.32px; font-size: 16.8px; font-family: sans-serif; transform:
scaleX(0.830048);" role="presentation" dir="ltr">sorbonne</span><span
style="left: 530.734px; top: 550.32px; font-size: 16.8px;
font-family: sans-serif;" role="presentation" dir="ltr">-</span><span
style="left: 535.836px; top: 550.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.829919);"
role="presentation" dir="ltr">universite</span><span
style="left: 601.982px; top: 550.32px; font-size: 16.8px;
font-family: sans-serif; transform: scaleX(0.806857);"
role="presentation" dir="ltr">.fr</span><br>
<br>
<pre class="moz-signature">--
___________________________________
Analytical Genomics Lab
Department of Computational and Quantitative Biology
UMR 7238 Sorbonne Université-CNRS
Campus Pierre et Marie Curie
Building C - 4th floor
4, place Jussieu, 75005 Paris
+33(0)1.44.27.73.45
<a class="moz-txt-link-abbreviated" href="mailto:Alessandra.Carbone@lip6.fr">Alessandra.Carbone@lip6.fr</a>
<a class="moz-txt-link-freetext" href="http://www.ihes.fr/~carbone/">http://www.ihes.fr/~carbone/</a>
<a class="moz-txt-link-freetext" href="http://www.lcqb.upmc.fr/AnalGenom/home.html">http://www.lcqb.upmc.fr/AnalGenom/home.html</a>
<a class="moz-txt-link-freetext" href="http://www.lcqb.upmc.fr/Contact">http://www.lcqb.upmc.fr/Contact</a> (for directions)
This message and any attachment are intended solely for the addressee
and may contain confidential information. Please do not use, copy or
disclose the information contained in this message or in any attachment.
</pre>
</div>
</body>
</html>